Certain drugs commonly used to treat hypertension, heart failure and damage caused by diabetes in the kidney are associated with a slightly increased risk of developing cancer, according to Scientists at Case Western Reserve University School of Medicine in Cleveland.
This finding, published in the online journal The Lancet Oncology, supports the need for more research to calculate, in the future, the exact risk of cancer associated with these drugs.
The ARBs act by blocking angiotensin II, a hormone that raisesd pressure. A previous study has demonstrated the existence of a significant increased risk of developing cancer in patients taking the ARBs candesartan, compared with placebo.
To analyze the effects of ARBs in malignancies, the team of researchers led by Ilke Sipahi, Case Western Reserve University School of Medicine in Cleveland, conducted a meta-analysis of all published data ARBs Randomized trials published before November 2009.
They studied new data from cancer in five trials involving 61 590 patients, common cancers in solid organs (lung, prostate and breast cancer) in five trials of 68 402 patients and cancer deaths in eight studies, which included 93 515 patients. Most of these trials examined patients which received the ARB telmisartan (85.7%).
The results showed that patients taking ARBs had a significant increase in the odds of being diagnosed with cancer, compared with the control group (7.2% vs. 6%).
Among the solid organ cancers examined, only the risk of lung cancer showed a significant increase in patients taking ARBs compared with the control group (0.9% versus 0.7%).
In addition, the data analyzed in the study were limited to three of the seven ARBs approved by FDA, telmisartan, losartan and candesartan. (http://www.sevensidedcube.net)
Monday 14 June 2010
Medal Of Honor Beta Drafting June 21st
If you aren’t already a Battlefield: Bad Company 2 player, or you are but don’t have plans to pre-order Medal of Honor, but you’re still interested in joining the Beta to see what all the fuss is about, you’re going to have to wait until June 21st. While BF:BC 2 users who pre-order are going to have a few days head start, the rest of you are just going to have to wait, you see. Don’t fret, however, as I think judging from the trailer, the multiplayer may just be worth it.
According to the EA press release, the Medal of Honor multiplayer beta features two heart-pounding modes set across two maps inspired by real world locations: Helmand Valley and Kabul City Ruins. In Team Assault mode, players must rely on their raw skill and map knowledge to stay alive in intense and close quarter combat. In Combat Mission, a tactical and team-based mode, gamers fight through a series of objectives revealed through an engaging narrative. Both modes pit two teams of 12 players (total 24 players) against one another with realistic destruction, tactical support actions, and a weapon customization system with modifications that generate hundreds of combinations.
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